Association of chemokine receptor gene (CCR2-CCR5) haplotypes with acquisition and control of HIV-1 infection in Zambians

Table 4 Proportional hazards analysis of the effect of CCR2-CCR5 haplotype or diplotype on HIV-1 acquisition.

	Overall				Male-to-Female				Female-to-Male
	(567 couples)				(295 couples)				(272 couples)
Cox model for individual CCR2-CCR5 haplotype or diplotype.
Haplotype/diplotype	N*	HR	95% CI	P**	N*	HR	95% CI	P**	N*	HR	95% CI	P**
*HHF2**	203	1.1	0.85-1.46	0.417	104	1.1	0.77-1.56	0.61	99	1.2	0.75-1.75	0.531
HHD	167	1.0	0.74-1.32	0.983	94	0.9	0.59-1.23	0.385	73	1.2	0.75-1.92	0.442
HHE	158	1.1	0.82-1.51	0.495	85	1.3	0.86-1.87	0.234	73	0.9	0.57-1.53	0.781
HHD/HHE	31	1.9	1.14-3.16	0.015	19	2.0	1.08-3.57	0.028	12	1.7	0.60-4.66	0.321
Multivariable model for CCR2-CCR5 HHD/HHE diplotype and HHF2 haplotype*.
Genetic factors	N*	HR	95% CI	P**	N*	HR	95% CI	P**	N*	HR	95% CI	P**
HHD/HHE	31	2.0	1.20-3.43	0.008	19	2.1	1.14-3.95	0.018	12	1.8	0.64-5.08	0.267
*HHF2**	203	1.2	0.90-1.57	0.222	104	1.2	0.83-1.72	0.337	99	1.2	0.77-1.82	0.439
Any genital ulcer or inflammation	299	3.6	2.65-4.93	< .0001	162	3.0	2.04-4.51	< .0001	137	4.6	2.79-7.65	< .0001
Donor VL (per 1.0 log ₁₀ unit)	523	1.6	1.32-1.91	< .0001	263	1.3	1.03-1.74	0.028	260	1.8	1.35-2.47	< .0001

*N represents the number of HESNs with each genotype.
**P values adjusted for genital ulcer, genital inflammation in either partner, and index partner log₁₀ VL.

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