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Table 4 Proportional hazards analysis of the effect of CCR2-CCR5 haplotype or diplotype on HIV-1 acquisition.

From: Association of chemokine receptor gene (CCR2-CCR5) haplotypes with acquisition and control of HIV-1 infection in Zambians

  Overall Male-to-Female Female-to-Male
  (567 couples) (295 couples) (272 couples)
Cox model for individual CCR2-CCR5 haplotype or diplotype.
Haplotype/diplotype N* HR 95% CI P** N* HR 95% CI P** N* HR 95% CI P**
HHF*2 203 1.1 0.85-1.46 0.417 104 1.1 0.77-1.56 0.61 99 1.2 0.75-1.75 0.531
HHD 167 1.0 0.74-1.32 0.983 94 0.9 0.59-1.23 0.385 73 1.2 0.75-1.92 0.442
HHE 158 1.1 0.82-1.51 0.495 85 1.3 0.86-1.87 0.234 73 0.9 0.57-1.53 0.781
HHD/HHE 31 1.9 1.14-3.16 0.015 19 2.0 1.08-3.57 0.028 12 1.7 0.60-4.66 0.321
Multivariable model for CCR2-CCR5 HHD/HHE diplotype and HHF*2 haplotype.
Genetic factors N* HR 95% CI P** N* HR 95% CI P** N* HR 95% CI P**
HHD/HHE 31 2.0 1.20-3.43 0.008 19 2.1 1.14-3.95 0.018 12 1.8 0.64-5.08 0.267
HHF*2 203 1.2 0.90-1.57 0.222 104 1.2 0.83-1.72 0.337 99 1.2 0.77-1.82 0.439
Any genital ulcer or inflammation 299 3.6 2.65-4.93 < .0001 162 3.0 2.04-4.51 < .0001 137 4.6 2.79-7.65 < .0001
Donor VL (per 1.0 log 10 unit) 523 1.6 1.32-1.91 < .0001 263 1.3 1.03-1.74 0.028 260 1.8 1.35-2.47 < .0001
  1. *N represents the number of HESNs with each genotype.
  2. **P values adjusted for genital ulcer, genital inflammation in either partner, and index partner log10 VL.