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Table 3 The impact of CCR2-CCR5 haplotypes on HIV-1 viral load in Zambian index partners and seroconverters

From: Association of chemokine receptor gene (CCR2-CCR5) haplotypes with acquisition and control of HIV-1 infection in Zambians

  Index partners Recent seroconverters
  (N = 567) (N = 240)
Viral Load Table for CCR5 haplotype/diplotype
Haplotype/diplotype N β ± SEa P* N β ± SEa P*
HHF*2 232 -0.21 ± 0.09 0.024 89 -0.10 ± 0.58 0.089
HHF*2/HHF*2 27 -0.08 ± 0.16 0.625 10 -0.70 ± 0.26 0.007
HHD (All) 164 -0.12 ± 0.06 0.052 69 0.24 ± 0.10 0.021
HHE (All) 131 0.13 ± 0.08 0.096 61 0.12 ± 0.12 0.339
HHD/HHE 18 -0.22 ± 0.20 0.270 16 0.49 ± 0.21 0.020
HHD/X (No HHE) 146 -0.11 ± 0.08 0.157 53 0.14 ± 0.13 0.284
HHE/X (No HHD) 113 0.19 ± 0.09 0.026 45 -0.06 ± 0.13 0.673
Multivariable Model for Interaction**
Haplotype/diplotype N β ± SEa P* N β ± SEa P*
HHD/X (No HHE or HHF*2) 109 -0.16 ± 0.09 0.560 37 0.24 ± 0.16 0.118
HHE/X (No HHD or HHF*2) 69 0.36 ± 0.11 0.002 31 0.10 ± 0.16 0.556
HHD/HHE 18 -0.16 ± 0.20 0.444 16 0.54 ± 0.22 0.014
HHF*2/HHF*2 27 -0.02 ± 0.16 0.918 10 -0.58 ± 0.26 0.027
HHF2/X (No HHD, HHE or HHF*2) 124 0.05 ± 0.09 0.602 49 0.10 ± 0.14 0.496
  1. a SE, standard error of the β estimate according to linear regression models.
  2. * P value adjusted for the sex and age at VL for all the individuals.
  3. ** Individuals with HHD/HHF*2, HHE/HHF*2 diplotypes are in the reference group in the multivariable model for interaction.