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Table 1 Demographic, epidemiologic and virologic characteristics of the HIV-1 nontransmission and transmission serodiscordant Zambian couples

From: Association of chemokine receptor gene (CCR2-CCR5) haplotypes with acquisition and control of HIV-1 infection in Zambians

  Nontransmission couples Transmission couples P
Characteristic    
Number of couples 327 240  
Male/Female (index partner) 148/179 147/93 0.0002
Age of partners (yrs)    
Index 31.5 ± 7.9 30.6 ± 7.8 0.170
Exposed 32.0 ± 8.3 28.6 ± 7.3 < 0.0001
Follow-up time (median [IQR], months) 31.5 [17.0-56.1] 17.7 [8.8-36.2] < 0.0001
Male circumcised    
   Index 8.8% 9.0% 0.970
   Exposed 19.5% 9.9% 0.053
Genital ulcers    
   Index 12.8% 36.6% < 0.0001
   Exposed 4.1% 26.3% < 0.0001
Genital inflammation a    
   Index 10.3% 26.3% < 0.0001
   Exposed 6.6% 29.1% < 0.0001
Any sexually transmitted disease    
Index 20.7% 50.2% < 0.0001
Exposed 10.0% 46.0% < 0.0001
HIV-1 RNA level (log10) in index partner 4.47 ± 0.90 4.96 ± 0.70 < 0.0001
HIV-1 RNA level (log10) in seroconverted partner   4.50 ± 0.80 NA
  1. a In the 3-6 months before HIV-1 transmission (transmission couples) or latest follow-up visit (nontransmission couples).