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Figure 3 | Retrovirology

Figure 3

From: Genome-wide analysis of primary CD4+ and CD8+ T cell transcriptomes shows evidence for a network of enriched pathways associated with HIV disease

Figure 3

Enrichment plot and heat map for the gene set of tricarboxylic acid cycle by GSEA. A. Enrichment plot for CD8+ T cells from the VIR group (VIR versus LTNP). Bottom, plot of the ranked list of all genes. Y axis, value of the ranking metric; X axis, the rank for all genes. Genes whose expression levels are most closely associated with the VIR or LTNP group get the highest metric scores with positive or negative sign, and are located at the left or right edge of the list. Middle, the location of genes from the gene set TCA cycle within the ranked list. Top, the running enrichment score for the gene set as the analysis walks along the ranked list. The score at the peak of the plot is the enrichment score (ES) for this gene set and those genes appear before or at the peak are defined as core enrichment genes for this gene set. B. Heat map of the genes within the gene set of TCA cycle corresponding to A. The genes that contribute most to the ES, i.e., genes that appear in the ranked list before or at the peak point of ES, are defined as core enrichment genes and highlighted by the red rectangle. Rows, genes, columns, samples. Range of colors (red to blue) shows the range of expression values (high to low). C. Enrichment plot for CD4+ T cells from the BDL group (BDL versus LTNP). D. Heat map of the genes within the gene set of TCA cycle corresponding to C.

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