Extensive complement-dependent enhancement of HIV-1 by autologous non-neutralising antibodies at early stages of infection

Table 1 Patient primary virus isolates

Patient	Virus	Day of virus isolation	C'-only enhancement (fold)
MM24	MM24.26	26	2.2
	MM24.464	464	2
MM25	MM25.18	18	2.4
MM26	MM26.62	62	2.1
	MM26.384	384	3.6
MM27	MM27.28	28	2
	MM27.585	585	3.8
MM28	MM28.6	6	2.1
MM32	MM32.10	10	3.1
MM33	MM33.12	12	3.4
MM34	MM34.32	32	9.7
	MM34.443	443	2.1
MM38	MM38.29	29	3.8
MM42	MM42.29	29	1.9
	MM42.238	238	2

Virus isolates are named according to patient ID (e.g. MM24) followed by a decimal point then the day of virus isolation. Days represent the time following onset of symptoms indicative of acute HIV infection. Viruses were isolated from patient PBMCs by co-culture, and expanded by minimal passage in fresh PBMCs. Fold increases in infection seen in the presence of complement alone (C'; i.e. in the absence of HIV-specific antibodies) compared to in the presence of heat-inactivated complement (HIC') are shown for each virus.

ISSN: 1742-4690