Figure 4
From: Retroviral matrix and lipids, the intimate interaction
Models for retroviral Gag membrane binding. Aa and Ba: formation of Gag dimers, association on gRNA. Ab: inhibition of HIV-MA membrane binding by gRNA. Ac: removal of gRNA resulting from competition between gRNA and PI(4,5)P2 for HIV-MA binding. Ad: Stabilization of the [R] conformation of MA by interaction with PI(4,5)P2, Gag trimerization, stabilization of membrane anchoring by PS, lateral targeting of Gag to assembly microdomains. Bb: Binding of MLV-MA to PI(4,5)P2. Bc: Secondary binding of MLV-MA to PS, stabilization the MA [R] conformation. Bd: lateral targeting of Gag to assembly microdomains.