From: Mutation of a diacidic motif in SIV-PBj Nef impairs T-cell activation and enteropathic disease
Virus | Macaque | Dose (TCID50) | Anorexia | Dehydration | Haemor. Diarrhea | Apathy | Rash |
---|---|---|---|---|---|---|---|
PBj-wt | #260 | 5 × 106 | + | + | + | + | - |
 | #250 | 5 × 105 | + | + | + | + | + |
 | #6504 | 5 × 105 | + | + | + | + | - |
PBj- Nef 202/203GG | #277 | 5 × 106 | - | - | - | - | - |
 | #267 | 5 × 105 | - | - | - | - | - |
 | #275 | 5 × 105 | - | - | - | - | - |
 | #276 | 5 × 105 | - | - | - | - | - |