Figure 9From: Highly conserved serine residue 40 in HIV-1 p6 regulates capsid processing and virus core assemblyCore morphology of wild type and mutant HIV-1 particles. (A) Electron micrographs showing thin sections of HeLa SS6 derived extra cellular particles of HIV-1NL-43 wt, the S40F mutant, the CA-SP1 Gag cleavage deficient mutant CA5, and the ALIX binding site mutant ΔYP. A higher-magnification view of representative particles illustrates the dominating core structures. (B) Quantitative assessment of the relative amount of particles with regular and irregular core morphology. About 100-120 unselected particles of the wt virus and each mutant were evaluated. The data are representative for four independent experiments.Back to article page