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Figure 5 | Retrovirology

Figure 5

From: The prototype HIV-1 maturation inhibitor, bevirimat, binds to the CA-SP1 cleavage site in immature Gag particles

Figure 5

Summary and analysis of analog-peptide adducts. (A) Pictorial representation of all labeled Gag fragments. The SP1 sequence is indicated in red. The MHR sequence is indicated in brown. The black arrowhead indicates the cleavage site between CA and SP1. Blue and red underlines represent C-28 and C-30 analog-peptide adducts, respectively; (B) Orientation of bevirimat on its target. Bevirimat is positioned parallel to the SP1 helix. Residues H358, L363, A364, A366, Q369, A370, and T371 are indicated. The last residue of the C-28 crosslinked region is indicated in blue, the whole C-30 crosslinked region is indicated in red. The remainder of the sequence is indicated in green. The model is shown in stick mode and dots show the van der Waals surfaces.

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