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Table 2 Clinical information and summary for Tax-specific CD8+ T cells in 14ACs

From: Functional impairment of Tax-specific but not cytomegalovirus-specific CD8+ T lymphocytes in a minor population of asymptomatic human T-cell leukemia virus type 1-carriers

ID

Age

Sex

WBC

(/μl)

CD4 (%)1

CD8 (%)1

HLA

Tetramer (%)2

Functions and phenotype of

Tax-specific CD8+ T-cells3

Ably (%)7

PVL8

        

IFN-γ+

(%)4

CFSElow

(%)5

PD-1+

(%)6

  

#217

70s

F

6800

ND9

5.72

A24

1.94

27.7

78.9

78.7

0

14

#236

30 s

F

6500

ND

11.9

A24

2.54

31.1

0

54.1

0

22

#238

60 s

F

5700

ND

12.7

A11

1.29

36.4

100

0

0

2

#243

50 s

F

4100

ND

24.6

A2/24

0.39/3.67

11.3

27.6

93.8

0

3

#245

40 s

F

5000

ND

22.6

A2

0.73

62.5

75

ND

1

58

#251

60 s

M

4800

ND

11.9

A2/11

0.70/8.23

35.8

84.4

36.7

0

2

#279

40 s

M

6200

34.1

11.6

A2/24

4.70/0.18

12.9

30.8

70.2

1

48

#287

70 s

M

4800

72.5

10.0

A2/24

1.17/0.23

11.1

0

55.6

2

81

#309

60 s

F

4600

37.5

24.8

A11/24

6.88/4.26

51.7

76.2

85.3

1.5

29

#311

60 s

F

3200

30.6

14.8

A2/24

1.02/1.94

51.3

ND

ND

0

6

#312

50 s

F

2700

27.3

36.4

A24

2.03

77.8

ND

ND

ND

UN10

#313

60 s

M

7300

25.4

31.0

A24

1.11

55.7

60

90.6

ND

4

#315

50 s

F

7500

26.5

7.9

A2/24

6.88/0

24.5

84.7

20

0.6

17

#360

50 s

M

6200

37.7

29.9

A2

2.6

63.1

68.4

10.2

0

UN

  1. 1The number indicates percentage of CD4+ or CD8+ T cells in lymphocytes.
  2. 2The number indicates percentages of tetramer+ cells in CD8+ T-cells. Two numbers divided by a slash represent those detected by two different tetramers corresponding to two HLA alleles shown in the HLA column.
  3. 3In case of a sample carrying two of three HLA-A alleles (A2, A11, or A24), Tax-specific CTLs predominantly detected by a tetramer were used. The number represents percentage of indicated cells in the tetramer-binding CD8+ T cells.
  4. 4Evaluated by intracellular IFN-γ staining following 6 hours stimulation with corresponding Tax peptide.
  5. 5Evaluated by CFSE intensities in labeled PBMC after 6 days incubation with corresponding Tax peptide stimulation.
  6. 6The number represents percentage of indicated PD-1+Tax-specific CD8+ T cells without culture.
  7. 7Ably; abnormal lymphocytes
  8. 8PVL; proviral load. The number represents copy number per 1000 PBMCs.
  9. 9ND; not determined
  10. 10UN; undetectable
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Retrovirology

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