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Table 2 Clinical information and summary for Tax-specific CD8+ T cells in 14ACs

From: Functional impairment of Tax-specific but not cytomegalovirus-specific CD8+ T lymphocytes in a minor population of asymptomatic human T-cell leukemia virus type 1-carriers

ID Age Sex WBC
(/μl)
CD4 (%)1 CD8 (%)1 HLA Tetramer (%)2 Functions and phenotype of
Tax-specific CD8+ T-cells3
Ably (%)7 PVL8
         IFN-γ+
(%)4
CFSElow
(%)5
PD-1+
(%)6
  
#217 70s F 6800 ND9 5.72 A24 1.94 27.7 78.9 78.7 0 14
#236 30 s F 6500 ND 11.9 A24 2.54 31.1 0 54.1 0 22
#238 60 s F 5700 ND 12.7 A11 1.29 36.4 100 0 0 2
#243 50 s F 4100 ND 24.6 A2/24 0.39/3.67 11.3 27.6 93.8 0 3
#245 40 s F 5000 ND 22.6 A2 0.73 62.5 75 ND 1 58
#251 60 s M 4800 ND 11.9 A2/11 0.70/8.23 35.8 84.4 36.7 0 2
#279 40 s M 6200 34.1 11.6 A2/24 4.70/0.18 12.9 30.8 70.2 1 48
#287 70 s M 4800 72.5 10.0 A2/24 1.17/0.23 11.1 0 55.6 2 81
#309 60 s F 4600 37.5 24.8 A11/24 6.88/4.26 51.7 76.2 85.3 1.5 29
#311 60 s F 3200 30.6 14.8 A2/24 1.02/1.94 51.3 ND ND 0 6
#312 50 s F 2700 27.3 36.4 A24 2.03 77.8 ND ND ND UN10
#313 60 s M 7300 25.4 31.0 A24 1.11 55.7 60 90.6 ND 4
#315 50 s F 7500 26.5 7.9 A2/24 6.88/0 24.5 84.7 20 0.6 17
#360 50 s M 6200 37.7 29.9 A2 2.6 63.1 68.4 10.2 0 UN
  1. 1The number indicates percentage of CD4+ or CD8+ T cells in lymphocytes.
  2. 2The number indicates percentages of tetramer+ cells in CD8+ T-cells. Two numbers divided by a slash represent those detected by two different tetramers corresponding to two HLA alleles shown in the HLA column.
  3. 3In case of a sample carrying two of three HLA-A alleles (A2, A11, or A24), Tax-specific CTLs predominantly detected by a tetramer were used. The number represents percentage of indicated cells in the tetramer-binding CD8+ T cells.
  4. 4Evaluated by intracellular IFN-γ staining following 6 hours stimulation with corresponding Tax peptide.
  5. 5Evaluated by CFSE intensities in labeled PBMC after 6 days incubation with corresponding Tax peptide stimulation.
  6. 6The number represents percentage of indicated PD-1+Tax-specific CD8+ T cells without culture.
  7. 7Ably; abnormal lymphocytes
  8. 8PVL; proviral load. The number represents copy number per 1000 PBMCs.
  9. 9ND; not determined
  10. 10UN; undetectable