Functional impairment of Tax-specific but not cytomegalovirus-specific CD8+ T lymphocytes in a minor population of asymptomatic human T-cell leukemia virus type 1-carriers

Table 1 The number of blood samples with detectable Tax-specific CD8⁺ T-cells in all samples tested in this study

Tax/HLA tetramers used in this study	Disease Status
	AC	HAM/TSP	cATL
HLA-A*0201/Tax11-19	12/14¹	7/7	2/11
HLA-A*1101/Tax88-96	4/4	4/4	3/5
HLA-A*2402/Tax301-309	13/15	13/13	5/16
No. of tetramer⁺ samples/total no. of blood samples²	20/23 (87.0%)	18/18 (100%)	8/21 (38.1%)

¹ No. of samples with detectable Tax-specific CD8⁺ T-cells/total no. of samples carrying each HLA allele. When the frequency of tetramer⁺ cells was more than 0.04% of CD8⁺ T-cells, the sample was regarded as detectable.
² In case Tax-specific CD8⁺ T-cells was detectable by either tetramer in a sample carrying two of three HLA-A alleles above, the sample was regarded as positive.

ISSN: 1742-4690