Differences in the mannose oligomer specificities of the closely related lectins from Galanthus nivalis and Zea maysstrongly determine their eventual anti-HIV activity

Table 7 Competition of GNA, GNA_maize and 2G12 mAb for binding to HIV-1 gp120

CBA	#RU at 2 min post injection	additional gp120 binding by the analyte (%)
5 μM GNA	409 ± 7
20 μM GNA_maize	111 ± 8
3 μM 2G12	313 ± 48
5 μM GNA + 20 μM GNA_maize	38 ± 4	34 ± 1.4
20 μM GNA_maize + 5 μM GNA	310 ± 6	76 ± 0.2
3 μM 2G12 + 5 μM GNA	287 ± 5	70 ± 0.0
5 μM GNA + 3 μM 2G12	78 ± 5	25 ± 5.4
3 μM 2G12 + 20 μM GNA_maize	93 ± 17	85 ± 21.3
20 μM GNA_maize + 3 μM 2G12	277 ± 4	89 ± 14.9

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