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Table 3 Inhibitory activity of GNAmaize and GNA on DC-SIGN-mediated capture of HIV-1(IIIB) by DC-SIGN+ cells and subsequent virus transmission to CD4+ T cells

From: Differences in the mannose oligomer specificities of the closely related lectins from Galanthus nivalis and Zea maysstrongly determine their eventual anti-HIV activity

CBA

EC50a(ÎĽM)

 

Capture

Transmission

GNAmaize

0.90 ± 0.40

0.44 ± 0.09

GNA

0.04 ± 0.01

0.006 ± 0.005

  1. a50% Effective concentration required to inhibit HIV-1 capture by DC-SIGN and subsequent transmission to CD4+ T-cells.
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Retrovirology

ISSN: 1742-4690

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