Differences in the mannose oligomer specificities of the closely related lectins from Galanthus nivalis and Zea maysstrongly determine their eventual anti-HIV activity

Table 1 Anti-HIV activity of GNA_maize and GNA in different cell systems

CBA	HIV-1(III_B) EC₅₀^a(μM)	HIV-2(ROD) EC₅₀^a(μM)	HuT-78/HIV-1 + Sup T1 EC₅₀^b(μM)
GNA_maize	0.46 ± 0.13	≥ 0.83	>1.67
GNA	0.007 ± 0.001	0.008 ± 0.001	0.062 ± 0.064

^a50% Effective concentration or compound concentration required to inhibit virus-induced cytopathicity in CEM cell cultures by 50%.
^b50% Effective concentration or compound concentration required to inhibit syncytia formation between HuT-78/HIV-1 and Sup-T1 cells by 50%.
Data are means of at least two to four independent experiments.

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