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Figure 3 | Retrovirology

Figure 3

From: Revisiting HIV-1 uncoating

Figure 3

Schematic representation of the fates of viral capsids in the cytoplasm of newly infected cells. After entry into the cytoplasm, HIV-1 capsids that are on a path of productive infection remain intact and are transported towards the nucleus along the cytoskeleton. They uncoat at the nuclear membrane upon completion of reverse transcription. Premature uncoating, in the case of TRIM5α restriction or of unstable capsid mutants, leads to abortive infection. Similarly, compromised uncoating, in the case of incomplete reverse transcription or of hyperstable capsid mutants, also leads to a dead-end infection event.

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