Figure 1

Relevant sequence regions from clonal, nef amplified from plasma or from resting CD4+T cells. The date of sample acquisition and number of clones that are identical to the displayed sequences are noted. The HLA-B*57-restricted epitope YT9 (Nef 120-128) and the undefined epitope KG15 (nef 105-119) in ES3 are denoted by empty boxes outlined in blue and yellow respectively. The HLA-B*57-restricted epitopes KF9 (Nef 82-90), and HW9 (Nef 116-124), are denoted by boxes shaded in green and pink respectively. Sequences from 2004 and 2005 for ES3, ES7, ES8, and ES9 have been previously reported and are shown for comparative purposes only.