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Table 1 The substitution rate, frequency of G-to-A and silent mutations, and the ratios of non-synonymous to synonymous mutations in RT-encoding fragment (codons 25-250) of NL4-3 and NLpolL(1084) viruses.

From: Subtype-associated differences in HIV-1 reverse transcription affect the viral replication

 

Substitution ratea

 

Viral Strain

Total mutations

× 10-4per nucl.

G-to-A mutations

× 10-4per nucl.

Silent mutations

× 10-4per nucl.

dN/dSb

NL4-3

6.39 ± 1.88

2.35 ± 1.10

1.19 ± 0.82

4.28

NLpolL(1084)

7.83 ± 1.75

1.97 ± 0.76

1.64 ± 0.70

3.62

  1. a calculated as a mean frequency of mutations per nucleotide for each viral strain on the base of single genome PCR and sequence analysis of proviral genomes.
  2. b ratio of non-synonymous to synonymous mutations per site.
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Retrovirology

ISSN: 1742-4690

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