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Table 1 The substitution rate, frequency of G-to-A and silent mutations, and the ratios of non-synonymous to synonymous mutations in RT-encoding fragment (codons 25-250) of NL4-3 and NLpolL(1084) viruses.

From: Subtype-associated differences in HIV-1 reverse transcription affect the viral replication

  Substitution ratea  
Viral Strain Total mutations × 10-4per nucl. G-to-A mutations × 10-4per nucl. Silent mutations × 10-4per nucl. dN/dSb
NL4-3 6.39 ± 1.88 2.35 ± 1.10 1.19 ± 0.82 4.28
NLpolL(1084) 7.83 ± 1.75 1.97 ± 0.76 1.64 ± 0.70 3.62
  1. a calculated as a mean frequency of mutations per nucleotide for each viral strain on the base of single genome PCR and sequence analysis of proviral genomes.
  2. b ratio of non-synonymous to synonymous mutations per site.