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Table 2 RT inhibitor susceptibilities for HIV-1 subtype B and subtype C viruses

From: Comparative biochemical analysis of recombinant reverse transcriptase enzymes of HIV-1 subtype B and subtype C

RT inhibitors

EC50(nM)a

 

Subtype B HIV-1

Subtype C HIV-1

ZDV

12.9 ± 5.9

34.8 ± 12.9

3TC

45.4 ± 16.4

105.9 ± 40.2

TFV

334.8 ± 140.9

304.8 ± 93.1

NVP

50.2 ± 29.6

170.4 ± 79.5

EFV

0.6 ± 0.2

1.3 ± 0.4

ETR

0.9 ± 0.4

0.5 ± 0.01

  1. a Data represent means ± standard deviations of three determinations.