Figure 2

Generation of Leukemic Stem Cells. Three hypotheses have been proposed that lead to the development of leukemic stem cells (LSC/CSC): (A) LSC/CSC might arise from either a hematopoietic stem cell (HSC), hematopoietic progenitor cell (HPC), committed lymphoid progenitor (CLP) or committed myeloid progenitor (CMP), (B) from a multipotent HSC or HPC into LSC/CSC through a single transformation event or, (C) from HSC or HPCs through a series of transformation events initiated by the generation of a pre-LSC/CSC.