Figure 1

Hematopoiesis and retroviral infection: CD34⁺ hematopoietic stem cells (HSCs) can undergo self-renewal as well as undergoing maturation to give rise to common lymphoid progenitor (CLP) and common myeloid progenitor (CMP) cells, which serve as precursors to all lymphoid and myeloid cells respectively. HSCs as well as other lineage specific progenitors are permissive for infection by a variety of murine and human retroviruses including HIV-1 and HTLV-1.