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Figure 4 | Retrovirology

Figure 4

From: GPI-anchored single chain Fv - an effective way to capture transiently-exposed neutralization epitopes on HIV-1 envelope spike

Figure 4

Potent inhibition of HIV-1 by GPI-scFv (X5) does not require additional sCD4. sCD4: soluble, extracellular domains of human CD4; w/o or w/sCD4: with or without pre-incubation of viruses with sCD4; y-axis: mean and standard deviation of relative luciferase activity; mock: negative control, background relative luciferase activity in uninfected TZM.bl cells. A.Cells infected with 400 TCID50 of HIV-1 Bru-3 with or without pre-incubation with sCD4; B.Cells infected with 4,000 TCID50 of HIV-1 Bru-3 with or without pre-incubation with sCD4; C.Cells infected with 400 TCID50 of HIV-1 Bru-Yu2 with or without pre-incubation with sCD4; D.Cells infected with 4,000 TCID50 of HIV-1 Bru-Yu2 with or without pre-incubation with sCD4.

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