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Figure 2 | Retrovirology

Figure 2

From: Effect of a short-term HAART on SIV load in macaque tissues is dependent on time of initiation and antiviral diffusion

Figure 2

Viral dynamics in SIV-infected macaques receiving a short-term post exposure HAART. Four hours after SIV intravenous inoculation, 2 groups of 4 macaques received either the AZT/3TC/IDV combination (HAART 4h-d14) or a placebo (placebo d14), then were killed at the end of treatment (14 days pi). After intravenous infection, post exposure HAART controlled the plasma (a) and the cell associated viral load (b). In tissues collected 14 days after inoculation the viral dissemination (c) and replication (d, e) were almost undetectable in HAART 4h-d14 animals (black symbols), whereas placebo d14 animals demonstrated extensive viral propagation (c) and replication (d,e) (open symbols). *: indicated a significant difference (p < 0.05) using a Mann-Whitney test. LN: lymph node, G mean: geometric mean. The grey area indicates the quantitative threshold of our qRT-PCR and qPCR assays.

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