Viral dynamics in SIV-infected macaques receiving a short-term HAART during early chronic infection. Among 9 SIV infected macaques at the set point of infection (150 days pi), 3 animals were untreated and killed (chronic untreated: open symbols), 3 animals received a 14 day long (chronic HAART 14d: black symbols) or a 28 day long (chronic HAART 28d: grey symbols) AZT/3TC/IDV treatment and were killed at the end of treatment. In the blood, the treatment induced a decrease of the plasma viral load (a), but a weak impact on the cell associated viral load (b). In tissue, total SIV DNA and 2LTR circles were almost constant in spleen and lymph nodes but reduced in gut (c, d). The treatment reduced the SIV RNA level in all tissues, with a slightly more important decrease in the gut than in the spleen or LN (e). *: indicated a significant difference (p < 0.05) using a Mann-Whitney test. ND: not determined due to the unavailability of ileum samples for placebo animals, LN: lymph node, G mean: geometric mean. The grey area indicates the quantitative threshold of our qRT-PCR and qPCR assays.