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Table 2 Drug resistance mutations by tissue source

From: Higher levels of Zidovudine resistant HIV in the colon compared to blood and other gastrointestinal compartments in HIV infection

Patient #7 PBL Esophagus Stomach Duodenum Colon
Visit 1      
  None (100%) None (20%) None (25% ND ND
ddI   T215Y (20%) L74V (8.3%)   
   M41L, T215Y (40%) T215Y (16.7%)   
   M41L, T69N, T215Y (20%) L74V, T215Y (50%)   
Visit 2      
  M41L, L74V, T215Y (100%) T215Y (100%) None (45.5%) M41L, T215Y(54.5%) M41L(33.3%)
ddI    M41L, L74V, T215Y (9.1%) T215Y (27.3%) L210W, T215Y(22.2%)
    T215Y (36.4%) M41L, L74V, T215Y (18.2%) None (44.4%)
    L74V, T215Y (9.1%)   
Visit 3      
  None (87.5%) M41L (42.9%) T215Y(93.8%) M41L (18.2%) M41L, L210W, T215Y(71.4%)
AZT F77S (12.5%) T215Y (57.1%) L210F, T215Y(6.25%) None (81.8%) M41L (14.3%)
      M41L, V75G (14.3%)
Visit 2007      
  None (100%)     
HAART      
Patient #60 PBL Esophagus Stomach Duodenum Colon
Visit 1      
  D67N, K70R, T215Y, K219Q (80%) None (90%) None (8.3%) D67N, T69N, K70R, K219Q (100%) D67N, K70R, K219Q (30%)
AZT D67N, K70R, K219Q (20%) E44K (10%) M41L (8.3%)   D67N, T69N, K70R, K219Q (50%)
    K70R, T215Y(83.3%)   D67N, T69N, K70R, F116V, K219Q (10%)
      E44V, D67N, T69N, K70R, K219Q (10%)
Visit 2      
  None 100% D67N, T69N, K70R, K219Q (90%) K70R, T215F (10%) D67N, K70R, K219Q (50%) D67N, K70R, T215Y, K219Q (40%)
AZT   K70R, T215Y (10%) D67N, T69N, K70R, K219Q (10%) D67N, T69N, K70R, K219Q (50%) D67N, T69D, K70R, T215Y, K219Q (60%)
    K70R, T215Y (80%)   
Visit 3      
  None (90.9%) D67N, T69N, K70R, K219Q (10%) ND None (45.5%) M184T (15.4%)
ddI M41T (9.1%) D67G, K70R, T215Y (10%)   K70R, T215Y(18.2%) D67N, T69D, K70R, T215F, K219Q (76.9%)
   D67N, K70R, K219Q (10%)   K70R, T215Y, K219Q (9.1%) D67N, T69D, K70R, V75I, T215F, K219Q (7.7%)
   K70R, T215Y (70%)   D67N, K70R, T215Y, K219Q (9.1%)  
     D67N, T69D, K70R, T215Y, K219Q (9.1%)  
     D67N, T69N, K70R, T215Y, K219Q (9.1%)  
Patient #19 PBL Esophagus Stomach Duodenum Colon
Visit 1      
  M41I, E44K, D67N, L74V (100%) K70R (10%) M41I, E44K, D67N, L74V (40%) ND ND
AZT   E44G (10%) None (60%)   
   F77S (10%) None (60%)   
   D67N, K70R, V118I, T215Y, K219Q (10%)    
Visit 2      
  M41L, T215Y (100%) None (77.8%) T215Y (100%) None (50%) F116K (14.3%)
AZT   D67G (11.1%)   L74V (50%) None (85.7%)
   T215A (11.1%)    
Visit 3      
  T215Y(20%) M41L, T215Y (100%) None (25%) None (77.8%) M41L, L74V, T215Y (66.7%)
AZT M41L, T215Y (80%)   K70R (50%) T215Y (11.1%) None (33.3%)
    L210W, T215Y (16.7%) M41L, D67G (11.1%)  
    M41L, L210W, T215Y (8.3%)   
Visit 2007      
  None (81.8%)     
HAART M41L, E44D, T215C (18.2%)     
Patient #42 PBL Esophagus Stomach Duodenum Colon
Visit 1      
  D67N, K70R, V118I, T215Y, K219Q (70%) K70R, T215Y(100%) None (58.3%) M184T (9.1%) D67N, K70R, V118I, T215F, K219Q (100%)
none D67N, K70R, V118I, L210F, T215F, K219Q (10%)   D67N, K70R, V118I, T215Y, K219Q (41.7%) D67N, T69D, K70R, T215F, K219Q (45.5.%)  
  D67N, K70R, F116Y, V118I, T215F, K219Q (10%)    None (45.5%)  
  E44D, D67N, K70R, V118I, T215F, K219Q (10%)     
  1. *ND - no viral sequences detected. Primary drug resistance mutations associated with high levels of drug resistance indicated in italics