Figure 2

Representative bootstrap Neighbor-Joining trees of RT-coding sequences obtained from gut tissues (esophagus (E), stomach (S), duodenum (D), colon (C)) and PBL (L) (indicated by different shapes and shading). RT sequences grouped by individual gut tissue and PBL to varying degrees in the different patients. Upon closer examination of the drug-resistance mutations indicated at each branch, grouping of resistance mutations by gut tissue and PBL was observed. Differences in drug-resistance mutations were found in the different tissues and PBL. Similar differences were observed for RT sequences recovered from the tissues of other patients, indicating difference in distribution of drug-resistance in the gut. (Bootstrap values > 70 are indicated.)