Figure 1

Consensus mutations and schematic structures are similar between EIAV and HIV-1. a) Sequence analysis show 10 consensus amino acid mutational sites that have been identified between two Chinese vaccine-derived wild-type EIAV strains and two vaccine virus strains in the EIAV Env region ("--" means that this amino acid was deleted). b) Schematic illustration of gp145 mutants. The figure after the M represents the region of mutations made in the CN54 gp145. c) Schematic figure of the EIAV D510 V3, V4 regions and the HIV-1 CN54 V1, V2 regions. The left figure shows the EIAV V3, V4 regions; the right figure shows the HIV-1 V1, V2 regions. N-Glycosylation sites are shown as branched lines.