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Figure 2 | Retrovirology

Figure 2

From: Susceptibility of the human retrovirus XMRV to antiretroviral inhibitors

Figure 2

Intrinsic resistance of XMRV to protease inhibitors (PIs). For XMRVVP62+LtatSN (shaded bars), HTX/LtatSN cells were infected with virus derived from the pVP62 clone, seeded into microtiter plates, and immediately treated with the indicated doses of PIs. For HIV-1NL4-3 (solid bars), 293T/17 cells were seeded into microtiter plates, transfected with plasmid DNA encoding the full-length NL4-3 molecular clone, and treated with the indicated concentrations of each PI. The same PI stocks were used to treat both sets of virus-producing cultures. Supernatants from PI-treated HTX and 293T/17 cultures were then diluted and plated onto MAGIC-5A indicator cells to quantify infectious particles. Bars represent the percentage of β-gal+ FFU in supernatants from the PI-treated cultures, relative to untreated controls, and are the means ± standard deviations from two independent experiments with two or more determinations of FFU per drug treatment per experiment. See List of Abbreviations for drug names.

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