Skip to main content

Table 2 CTL escape at the Gag p11c epitope in breast milk and blood virus quasispecies during acute SIV infection.

From: Local replication of simian immunodeficiency virus in the breast milk compartment of chronically-infected, lactating rhesus monkeys

 

Weeks after SIV infection

Animal #

Week 33

Week 35

Week 36

Week 37

Week 38

Week 40

Week 45

206

blood

100%a

(14/14)b

65.4%

(17/26)

59.4%

(19/32)

61.5%

(16/26)

41.7%

(10/24)

30.4%

(7/23)

8.3%

(2/24)

 

milk

80%

(4/5)

29.0%

(9/31)

83.3%

(35/42)

3.1%

(1/32)

NDc

ND

ND

  

Week 37

Week 39

Week 41

Week 42

Week 45

Week 46

 

257

blood

100%

(16/16)

ND

ND

100%

(28/28)

21.2%

(7/33)

0%

(0/17)

 
 

milk

ND

50%

(5/10)

0%

(0/5)

ND

14.3%

(1/7)

6.7%

(1/15)

 
  

Week 33

Week 35

Week 36

Week 37

   

402

blood

0%

(0/22)

0%

(0/35)

0%

(0/27)

0%

(0/19)

   
 

milk

0%

(0/22)

12.5%

(1/8)

0%

(0/15)

0%

(0/5)

   
  

Week 15

Week 16

Week 17

    

403

blood

73.1%

(19/26)

28.0%

(7/25)

0%

(0/26)

    
 

milk

100%

(15/15)

18.5%

(5/27)

4.3%

(1/23)

    
  1. a % reported is the proportion of virus quasispecies that did not have an amino acid substitution within the Gag p11C epitope (remained wild type).
  2. b In parentheses is the number of virus quasispecies that remained wild type at the Tat TL8 epitope/number of virus quasispecies sequenced.
  3. c ND = not done or unable to amplify virus variants