Figure 9

Schematic diagram representing the alteration of signaling network by Sprouty2 and Env. Schematic diagram represents the interaction of signaling molecules and their proposed physiological outcomes. The levels of phospho Akt, phospho ERK, Sprouty2 and phospho STAT3 in the cell lines A549, A549-Spr, A549-Y55FSpr/A549-Y227FSpr and A549-Env are represented. ↑ indicates upregulation, ↓ indicates downregulation, + indicates presence without any increase or decrease. The functional outcomes in terms of proliferation, tumor formation, migration and anchorage-independent colony formation in the above mentioned cell lines are also represented.