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Figure 3 | Retrovirology

Figure 3

From: Functional interaction between Envoncogene from Jaagsiekte sheep retrovirus and tumor suppressor Sprouty2

Figure 3

Env enhances and Sprouty2 inhibits tumor formation in SCID mice. (A) Pictures of in vivo tumors formed by A549, A549-Spr and A549-Env cells injected into the subcutaneous tissue of SCID mice (5-7 mice per group) and excised on day 34. (B) The growth rate of tumors formed by the respective cell lines in SCID mice is represented as increase in tumor volume monitored for up to 5 weeks. (C) Average weight of tumors resected from SCID mice 34 days after injection (*P = 0.0003, **P = 0.0006). (D) Hematoxylin and eosin (H&E) staining of sections of xenografts resected from SCID mice to confirm the presence of malignant cells. Magnification 400×.

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