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Figure 4 | Retrovirology

Figure 4

From: Analysis of infectious virus clones from two HIV-1 superinfection cases suggests that the primary strains have lower fitness

Figure 4

HIV-1 LTR and Tat sequences. (A) Nucleotide sequences of the LTR region from clones B1.1, B1.3, B2.3 (primary and superinfecting strain from patient L, respectively), and clones B3.1, B4.2, and B4.4 (primary and superinfecting strain from patient P, respectively). Sequences were aligned using the HXB2 sequence (GenBank acc. no. K03455) as reference. Binding sites for transcription factors and the two insertions found in clone B1.1 (type I and type II) have been boxed. A NF-κB/NFAT binding site immediately followed by an YY1 binding site found only in clone B1.1, are indicated. The TATA-box and the TAR region (nt 504-555) have been underlined. A destabilizing T→C mutation in the TAR hairpin region in clone B2.3 is boxed. The polyA hairpin (nt 556-602) is shown in bold, a box indicates the destabilizing TT→CA mutation in clone B3.1. (B) Translated amino acid sequences are shown for HIV-1 Tat. Sequences have been aligned with the HXB2 sequence. Clone numbers are indicated. Strains B1 and B2 are the first and superinfecting virus from patient L, respectively. Strains B3 and B4 are the first and superinfecting virus from patient P, respectively. The Tat T23 N and F32 L mutations in strain B1 associated with increased and decreased Tat activity have been boxed.

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