Table 2 Performance evaluation of ESTA X4-dual/mixed tropism prediction using geno2pheno clinical and clonal at 10% FPR, or the clonal at the optimised 5.75% FPR interpretation of contemporary viral gp120 V3 DNA or RNA genotyping
Viral sample | geno2pheno interpretation mode (FPR) | AUROC | accuracy | sensitivity | specificity |
|---|---|---|---|---|---|
plasma RNA (n = 35) | Clinical (10%) | 0.83 | 80.0% | 90.9% | 75.0% |
| Â | Clonal (10%) | 0.67 | 71.4% | 54.5% | 79.2% |
| Â | Clonal optim. (5.75% ) | 0.75 | 82.9% | 54.5% | 95.8% |
whole-blood DNA (n = 17) | Clinical (10%) | 0.86 | 76.5% | 100% | 71.4% |
| Â | Clonal (10%) | 0.69 | 70.6% | 66.7% | 71.4% |
| Â | Clonal optim. (5.75% ) | 0.76 | 82.3% | 66.7% | 85.7% |