Transcriptome analysis of monocyte-HIV interactions

Retrovirology

Table 3 Overrepresentation of biological processes in differential gene expression data of monocytes from therapy-naïve HIV patients

Class	GO term	GO ID¹	z-score²	p-value³³
Apoptosis/DNA damage
	induction of apoptosis	6917	2.622	0.03
	response to radiation	9314	3.198	0.017
Cell cycle
	cell maturation	48469	3.862	0.006
	positive regulation of cell proliferation	8284	3.062	0.009
Lipid Metabolism
	Hs_Adipogenesis	User	2.896	0.018
Proteasome activity
	cysteine-type endopeptidase activity	4197	4.486	0.009
	Proteolysis	6508	1.996	0.044
	ubiquitin cycle	6512	2.271	0.041
	ubiquitin-protein ligase activity	4842	2.527	0.05
Protein trafficking
	protein import into nucleus	6606	4.732	0.001
Transcriptional regulation
	DNA binding	3677	2.929	0.003
	negative regulation of transcription	16481	3.207	0.012
	transcription regulator activity	30528	2.534	0.017
	negative regulation of transcription\, DNA-dependent	45892	2.422	0.038

GO: Gene Ontology; ¹: the official GO identification code for the process http://www.geneontology.org, "User" denotes a user contributed pathway; ²: the score for the standard statistical test under the hypergeometrical distribution, as calculated by MAPPFinder; ³: the permute p-value as correction on the z-score, as calculated by MAPPFinder; GO terms shown in boldface were identified using both the stringent and less stringent criteria, other terms were only found using the less stringent criteria.

ISSN: 1742-4690