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Table 3 Inhibition of HIV-1 replication

From: Anticipating and blocking HIV-1 escape by second generation antiviral shRNAs

  shRNAs
Target wt G8A G15A wt+G8A wt+G8A+G15A
wt ++a (0)b - (1) - (1) ++ (0.1)c ++ (0.1.1)c
G8A - (1) ++ (0) - (1) ++ (1.0) ++ (1.0.1)
G15A - (1) - (1) ++ (0) - (0.1) ++ (1.1.0)
+G8A+G15A - (2) - (1) ++ (1) - (2.1) - (2.1.1)
  1. a score of RNAi activity
  2. b number of mismatches
  3. c number of mismatches per shRNA