Skip to main content

Table 3 Inhibition of HIV-1 replication

From: Anticipating and blocking HIV-1 escape by second generation antiviral shRNAs

 

shRNAs

Target

wt

G8A

G15A

wt+G8A

wt+G8A+G15A

wt

++a (0)b

- (1)

- (1)

++ (0.1)c

++ (0.1.1)c

G8A

- (1)

++ (0)

- (1)

++ (1.0)

++ (1.0.1)

G15A

- (1)

- (1)

++ (0)

- (0.1)

++ (1.1.0)

+G8A+G15A

- (2)

- (1)

++ (1)

- (2.1)

- (2.1.1)

  1. a score of RNAi activity
  2. b number of mismatches
  3. c number of mismatches per shRNA