Modulation of HIV-1 macrophage-tropism among R5 envelopes occurs before detection of neutralizing antibodies

Retrovirology

Table 2 Envelope residues potentially involved in modulating macrophage-tropism

Subject	Days post onset of symptoms	Env clone	Mac infn	Potential amino acid tropism determinants
				No. amino acid changes in gp120	Env region	Amino acid changes
MM1	28	1.2.1	-	5	V3 loop	NNSRKGIHIGPGRAFY
		1.2.3	+			--T-----------L-
MM4	17	4.1.33	-	5	β24-α5	GGD ¹
		4.1.34	+			--N
	493	4.10.1	-	3	β24-α5	GGDMG¹
		4.10.3	+			----R
MM8	608	8.8.1	-	11	β20-β21	NRWQEA ¹
		8.8.3	+			-----V

1. Amino acids that are CD4 contact residues are underlined on upper sequences [26].

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