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Table 4 Antiviral activities of ML-OVA against infection by HIV-1, HIV-2, SHIV, SIV and HSV-2 strains.

From: Maleic anhydride-modified chicken ovalbumin as an effective and inexpensive anti-HIV microbicide candidate for prevention of HIV sexual transmission

Virus strain

Inhibitory activity (Mean ± SD, μM)a

 

IC50

IC90

Laboratory-adapted HIV-1 strains

  

   IIIB (X4)

0.023 ± 0.004

0.057 ± 0.004

   MN (X4)

0.151 ± 0.008

0.821 ± 0.103

   RF (X4R5)

0.034 ± 0.005

0.147 ± 0.059

   BaL (R5)

0.690 ± 0.109

2.236 ± 1.184

Primary HIV-1 strains

  

   UG94103(clade A, X4R5)

0.561 ± 0.159

2.520 ± 1.231

   92US657 (clade B, R5)

2.107 ± 0.263

9.357 ± 1.939

   93IN101 (clade C, R5)

1.208 ± 0.535

4.946 ± 0.632

   BCF02 (clade O, R5)

0.067 ± 0.004

0.188 ± .0.010

   Ru570 (clade G, R5)

4.299 ± 0.298

9.332 ± 0.594

Drug-resistant HIV-1

  

   AZT-R b

0.296 ± 0.052

1.099 ± 0.773

   NL4-3D36Gc

0.104 ± 0.019

0.591 ± 0.059

   NL4-3(36G)V38A c

0.185 ± 0.027

0.543 ± 0.026

   NL4-3(36G)V38E/N42T c

0.156 ± 0.082

0.992 ± 0.438

HIV-2

  

   ROD

6.079 ± 1.907

12.59 ± 3.022

SIV

  

   mac 251 32H

0.307 ± 0.174

6.128 ± 2.078

SHIV

  

   SF33A (X4)

0.189 ± 0.103

1.505 ± 0.872

   SF162P3 (R5)

1.312 ± 0.688

11.63 ± 5.477

HSV

  

   HSV-2 strain 333

39.06 ± 2.316

69.49 ± 3.145

  1. aThe measurements were performed in triplicate, and the experiment was repeated at least twice;
  2. bRTI-resistant strain;
  3. c Enfuvirtide-resistant variants.