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Figure 7 | Retrovirology

Figure 7

From: Response of a simian immunodeficiency virus (SIVmac251) to raltegravir: a basis for a new treatment for simian AIDS and an animal model for studying lentiviral persistence during antiretroviral therapy

Figure 7

A three-dimensional model of SIVmac251 IN catalytic core domain colored by amino acid similarity with wild-type HIV-1 IN. The enzyme is coloured by sequence similarity with its HIV-1 orthologue [PDB:1BL3]. The level of similarity was calculated by the Swiss PDB Viewer (SPDBV) software. The colour scale is that adopted by SPDBV. Similarity is maximal at the level of the INSTI/cellular DNA binding site (indicated by a semi-transparent grey circle), as calculated by some of us in previous works [35]. Image obtained using PyMOL [73].

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