Figure 7

Hepcidin induces HIV-1 production in primary human monocytes and CD4⁺ T cells. Human primary monocytes (A) and human primary CD4+ T cells (B) were infected with dual tropic HIV-1 89.6 strain. At 24 hrs postinfection, the cells were treated with 0.3 μM hepcidin for 3 hrs and then with 100 μM FAC for 24 hrs. At 48 hours postinfection, the medium was collected, and RT was measured.