The mouse

Retrovirology

Table 4 Sequence comparisons of coding and non-coding domains of XMRV and 5 full length gammaretrovirus genomes.

		DG75 X-MLV AF221065	Bxv1 XmvAC115959	Mpmv1 PmvAC127565	MCF1233 P-MLV U13766	AKV E-MLV J01998
LTR	U5	90	100	90	99	93
	R	95	100	96	99	95
	U3	87	94	85	84	84
*gag*	*gag* leader	85	86	90	85	85
	MA	90	86	98	84	87
	p12	97	81	99	82	81
	CA	99	88	99	89	87
	NC	98	96	99	92	92
*pol*	PR	99	92	99	92	92
	RT	94	93	95	92	93
	IN	92	93	97	89	86
*env*	SU	94	95	89	90	< 75
	TM	98	98	98	83	81

Numbers represent percent identity. DG75 is an X-MLV isolated from the human DG-75 lymphoblastoid line [120], MCF1233 and AKV MLV are infectious viruses isolated from AKR strain mice. Bxv1 is the active endogenous xenotropic ERV found in strains such as C57BL and BALB/c. AKV has a duplicated enhancer in U3 that was not included in the analysis. Mpmv1 is a full-length ERV in the sequenced C57BL genome; it contains a 190 bp LTR insert that was not included in the analysis. GenBank accession numbers are provided for the 5 sequences; comparisons were done with VP62 XMRV NC_007815.

ISSN: 1742-4690