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Figure 4 | Retrovirology

Figure 4

From: Vpu serine 52 dependent counteraction of tetherin is required for HIV-1 replication in macrophages, but not in ex vivo human lymphoid tissue

Figure 4

Vpu S52A is dispensable for HIV-1 replication and cytopathicity in ex vivo infected HLT. Representative replication kinetics (A) of the indicated X4 and R5 HIV-1 NL4-3 constructs. (B) Cumulative p24 production over 15 days and (C) CD4+ T cells depletion at the end of culture in tissues from eight (X4) and ten (R5) donors infected with the indicated HIV-1 variants. Values are given as percentages compared to cultures infected with NL4-3 wildtype (100%). Shown are means +/- SEM. (D) Correlation between p24 production and CD4+ T-cell depletion.

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Retrovirology

ISSN: 1742-4690

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