Figure 1
From: Structural basis for HIV-1 DNA integration in the human genome
Proposed mechanism for thei ntegration of viral cDNA into the host genome: The LEDGF envelope is represented in blue; the integrase tetramer is shown as atomic structures. The viral DNA is in orange and the target DNA in red. On target DNA binding, there is a conformational change of the integrase proteins to position the viral DNA for the integration within 5 bases pairs in the target DNA.