Figure 1
From: Biochemical and virological analysis of the 18-residue C-terminal tail of HIV-1 integrase
IN sequence alignment and HIV-1 mutants analyzed in this study. The upper drawing indicates the three IN domains, with amino acid residues conserved among all retroviruses noted. CTD sequences downstream of the invariant Trp are shown below for HIV-1 (NL4-3 isolate, accession number M19921), SIVcpz (accession number AF115393), and HIV-2 (ROD isolate, accession number M15390). Residues that appear in more than one sequence are highlighted in grey. The broad arrows beneath the alignment indicate the β strands that comprise the SH3 fold [35, 36]. Numbers 266-285 above the alignment mark the IN deletion mutant enzymes and viruses analyzed in this study. The underline indicates the region of HIV-2 IN that was swapped for HIV-1 residues 271-288.