Figure 10

Comparison of predicted Tax amino acid sequences of selected prototypical primate T-cell lymphotropic viruses. Shown in boxes are known functional motifs: NLS, nuclear localization signal; (CBP)/P300, cAMP response element (CREB) binding protein; NES, nuclear export signal; CR2, C-terminal transcriptional activating domain; PDZ, PDZ binding motif; M1, M22, and M47 are motifs important for Tax transactivation and NF-kβ activation (38).