Perinatal acquisition of drug-resistant HIV-1 infection: mechanisms and long-term outcome

Delaugerre, Constance; Chaix, Marie-Laure; Blanche, Stephane; Warszawski, Josiane; Cornet, Dorine; Dollfus, Catherine; Schneider, Veronique; Burgard, Marianne; Faye, Albert; Mandelbrot, Laurent; Tubiana, Roland; Rouzioux, Christine

doi:10.1186/1742-4690-6-85

Retrovirology

Table 2 Longitudinal resistance analysis in newborns infected with drug resistant HIV-1

From: Perinatal acquisition of drug-resistant HIV-1 infection: mechanisms and long-term outcome

PERSISTENCE OF RESISTANCE MUTATION
					Resistance mutations in children
Patient	Birth year	Antiretroviral regimen	HIV-1 diagnosis sample	Resistance sample (Month)	HIV-1 RNA	HIV-1 DNA
1	1997	ZDV	Month 1	M1	70R	70R
		ZDV d4T ddI		M4		70R
		stop		M36	67N 70R 219E
		d4T ddI EFV		M48		67N 70R 101E/K 103N/K 190S/G 219E
7	2000		Birth	M0	(RT) 69N	69N
		d4T 3TC NFV NVP		M20	(RT) 69N 103N 181C 184V
		3TC NVP		M26	(RT) 69N 181C 184I
					(P) 20I 36I 71T/A 90M/L
		stop		M50	(RT) 69N 181C
					(P) 20I 36I
		stop		M58	(RT) 69N 181C
					(P) 20I 36I
8	2001	ZDV	Month 1	M1	101E 190A	101E 190A
		stop		M4	101E 190A
		d4T 3TC LPV/r		M12	101E 184V 190A
		d4T 3TC LPV/r		M36		101E 106I/V 190A
		d4T 3TC LPV/r		M48	101E 184V 190A	101E 106I 190A 184V
		d4T 3TC LPV/r		M55	184V 190A
9	2001	ZDV	Birth	M0	(P) 10I 63P 90M	(P) 10I 63P 90M
		d4T ABC NVP		M1	(P) 10I 63P 90M
		stop		M12		(P) 10I 63P 90M
		ABC 3TC NFV NVP		M18	(RT) 181C 184V
					(P) 10I 63P 90M
		ABC 3TC NFV NVP		M20	(RT) 181C 184V
					(P) 10I 63P 90M
		d4T ABC LPV/r		M32	(RT) 181C 184V
					(P) 10I 63P 71T 90M
		stop		M38	(RT) 101R/K 181C/Y
					(P) 10I 63P 71T 90M
		ZDV ABC ATV/r		M48	(RT) 101R/K 215I/T	(RT) 101R/K 215I/T
					(P) 10I 63P 71T 90M	(P) 10I 63P 71T 90M
		ZDV ABC ATV/r		M54	(RT) 215I/T 101R/K
					(P) 10I 63P 71T 90M
10	2001	ZDV	Month 3	M3	103N 181C 215Y	NA
		ZDV		M6	103N 181C 215Y
		ZDV 3TC LPV/r		M24	103N 181C 184V 215Y
		stop		M48	103N 181C 184V/M 215Y/D	103N 181C 184V/M 215Y
11	2004		Birth	M0
		ZDV 3TC		M1
		d4T ABC LPV/r		M3	184V	184V
		d4T ABC LPV/r		M7		184V
		d4T ABC LPV/r		M9	184V	184V
REVERSION OF RESISTANCE MUTATION
					Resistance mutations in children
Patient	Birth year	Antiretroviral regimen	First HIV-1 positive sample	Resistance sampling date	HIV-1 RNA	HIV-1 DNA
6	1999	ZDV	Birth	M0	67N/S	no mutation
		stop		M1		no mutation
		d4T ddI NFV		M12	no mutation	no mutation
12	2004	ZDV	Birth	M0	70R/K	no mutation
		ZDV		M2	70R/K	no mutation
		stop		M3	no mutation	no mutation
		stop		M12		no mutation
		stop		M18		no mutation
		stop		M24	no mutation

ZDV = zidovudine, 3TC = lamivudine, ddI = didanosine, d4T = stavudine, ABC = abacavir, NVP = nevirapine, EFV = efavirenz, NFV = nelfinavir, LPV/r = lopinavir/ritonavir, ATV/r = atazanavir/ritonavir
RT: reverse transcriptase; P: protease; Persistent mutations in bold; Empty line: resistance test was not done

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ISSN: 1742-4690

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