Perinatal acquisition of drug-resistant HIV-1 infection: mechanisms and long-term outcome

Retrovirology

Table 1 Perinatal antiretroviral exposition and drug resistance mutations in newborns and their respective mother

		Antiretroviral perinatal exposition					HIV-1 drug-resistance mutations*
Newborn	Birthyear	Mother	Intrapartum	Newborn	HIV-1 diagnosis sample	Viral subtype	in Newborns		in Mothers
							HIV-1 RNA	HIV-1 DNA	HIV-1 RNA	HIV-1 DNA
1	1997	ZDV	NA	ZDV	1 mo	B	70R	70R	70R/K	70R/K
2	1997	ZDV 3TC	ZDV	ZDV 3TC	birth	NA	41L, 184V	NA	41L, 184V, 215Y/F	NA
3	1997	ZDV 3TC	ZDV	ZDV 3TC	1 mo#	NA	70R, 184V	NA	70R,184V	NA
4	1998	-	-	ZDV	1 mo	CRF02	219Q/K	NA	181C	No mutation
5	1999	ZDV	-	ZDV	1 mo	B	70R	70R	NA	NA
6	1999	-	NA	ZDV	birth	F	67N/S	no mutation	no mutation	no mutation
7	2000	ZDV 3TC DDI	ZDV	ZDV	birth	CRF02	69N	69N	69N	69N
8	2001	ZDV DDI NVP	ZDV	ZDV	1 mo	B	101E, 190A	101E, 190A	NA	NA
9	2001	DDI SQV LPV/R	ZDV	ZDV	birth	B	(RT) no mutation	(RT) no mutation	(RT) 181C 210W 215D	(RT) 181C/Y 210W/L 215N/T
							(P) 10I 63P 90M	(P) 10I 63P 90M	(P) 10I 63P 90M 215Y	(P) 10I 63P 90M
10	2001	-	ZDV	ZDV	3 mo#	CRF02	103N 181C	NA	103N 181C 215Y	NA
11	2004	ZDV 3TC IDV/R	ZDV	ZDV 3TC	birth	B	184V	184V	no mutation	NA
12	2004	ZDV 3TC IDV/R	ZDV	ZDV	birth	A	70R/K	no mutation	no mutation	no mutation

* Genotypic analysis of resistance was performed on the HIV-1 diagnosis sample for the children (except for child #11, in whom resistance was analyzed at month 3) and at delivery for the mother Resistance mutations according to the IAS list 2007 were noted ((RT) reverse transcriptase; (P) protease)
ZDV = zidovudine, 3TC = lamivudine, DDI = didanosine, NVP = nevirapine, SQV = saquinavir, LPV/R = lopinavir/ritonavir, IDV/R = indinavir/ritonavir, dash "-" = untreated
# no prior available sample
NA not available

ISSN: 1742-4690