Figure 1
From: E box motifs as mediators of proviral latency of human retroviruses
Schematic representation of the proposed regulation of the HTLV LTR by E box proteins. Binding of E box proteins to the adjacent E box disrupts the interaction of TBP with the TATA element and may inhibit basal expression thus favoring proviral latency. In turn, the expression of a bHLH class II protein (like TAL1) should interfere with the binding of bHLH factors to the E box, thus restoring the basal retroviral expression and turning off latency.