Table 2 Defining Characteristics of Humanized Mouse Models
From: The utilization of humanized mouse models for the study of human retroviral infections
Model | Human Cells Engrafted | Irradiation | Demonstrated Human Cells | Humanized Tissues | Length of Detection |
|---|---|---|---|---|---|
SCID-hu Thy/Liv | Fetal thymus and liver | No | D4/CD8 DP, SP, DN, T cells in peripheral blood | Peripheral blood, fused thy/liv organ | 6 to ≥ 12 months |
hu-PBL SCID | IP PBMCs | No | CD4/CD8 SP T cells, CD3+ T cells, monocytes, NK cells, and B cells | Lymph nodes, spleen, liver, bone marrow | 6 months |
NOD SCID BLT | Fetal thymus and liver, fetal liver tissue-derived CD34+ stem cells | Yes | Mature T and B lymphocytes, monocytes, macrophages, and dendritic cells | Peripheral blood, liver, lung, vagina, rectum, and GALT | 22 weeks |
NOD SCID IL2r γ-/- | CD34+ human cord blood | Yes/No | Myelomonocytes, dendritic cells, erythrocytes, platelets, and lymphocytes | Peripheral blood, spleen, and bone marrow | > 300 days |
Rag2-/-γc-/- | CD34+ human cord blood | Yes | Dendritic, T, and B cells | Peripheral blood, liver, spleen, bone marrow, vagina, GALT | 190 days |
NOD SCID β2m | Transformed HTLV-1 cell lines, PBMCs from HTLV-1 infected patients | Yes/No | CD45+, CD3+, T cells | Peripheral blood, spleen, lymph node, bone marrow | 4 to 12 weeks |
NOD SCID IL2rγ null ("NOG") | Transformed HTLV-1 cell lines, PBMCs from HTLV-1 infected patients | No | CD4+, CD8+ T cells | Liver, spleen, lung, kidney | N/A |