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Figure 2 | Retrovirology

Figure 2

From: Modification of a loop sequence between α-helices 6 and 7 of virus capsid (CA) protein in a human immunodeficiency virus type 1 (HIV-1) derivative that has simian immunodeficiency virus (SIVmac239) vifand CA α-helices 4 and 5 loop improves replication in cynomolgus monkey cells

Figure 2

Replication properties of HIV-1 derivatives. Equal amounts of (A) NL-ScaVR (white diamonds: virus with SIVmac L4/5 and vif), and NL-ScaVRA1 (gray diamonds: virus with additional replacement of the 120th amino acid His with Gln in NL-ScaVR), and NL-ScaVR6/7S (black diamonds: virus with SIVmac L4/5, L6/7, and vif) (B) NL-SVR, NL-ScaVR6/7S, and NL-SVRS6/7S (gray diamonds: virus with SIVmac L6/7 and vif), and (C) NL-DT5R (white squares) and NL-DT5R6/7S (black squares), were inoculated into human MT4 or CM HSC-F cells, and culture supernatants were collected periodically. p24 antigen levels were measured by ELISA.

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