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Figure 1 | Retrovirology

Figure 1

From: Modification of a loop sequence between α-helices 6 and 7 of virus capsid (CA) protein in a human immunodeficiency virus type 1 (HIV-1) derivative that has simian immunodeficiency virus (SIVmac239) vifand CA α-helices 4 and 5 loop improves replication in cynomolgus monkey cells

Figure 1

Structure of the chimeric HIV-1/SIVmac clones and a summary of their replication capabilities. White bars denote HIV-1 (NL4-3) and gray bars SIVmac239 sequences. ++++, +++, ++, +, and -denote the peak titer of virus growth in human (Hu) and cynomolgus monkey (CM) cells, respectively, to more than 1000 ng/ml, 100–1000 ng/ml, 10–100 ng/ml, 1–10 ng/ml, and less than 1 ng/ml concentration of capsid (CA) protein in the culture supernatants. * denotes that NL-DT5R6/7S replicated faster in HSC-F than did the parental NL-DT5R (see Fig. 2C).

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