Discovery of novel targets for multi-epitope vaccines: Screening of HIV-1 genomes using association rule mining

Retrovirology

Table 2 Summary of the discovered CTL epitope association rules.

	Data sets
Association rules	62-all	44-non-CRFs	18-CRFs *	Pseudo-set
Number of epitope associations with support >= 0.75 * & confidence >= 0.95	1961	1095	1867	1944
Unique epitope associations^#
Associations with 2 epitopes ^$	46	48	45	46
Associations with 3 epitopes	217	166	71	217
Associations with 4 epitopes	153	102	59	151
Associations with 5 epitopes	59	26	27	58
Associations with 6 epitopes	9	2	7	9
Associations with 7 epitopes	0	0	1	0
*Total*	484	344	210	481
Unique epitope associations with epitopes from only one gene
Epitopes from Gag only	9	12	3	9
Epitopes from Pol only	94	81	47	94
Epitopes from Nef only	0	0	0	0
*Total*	103	93	50	103
Unique epitope associations with epitopes from two genes
Gag-Pol	329	234	145	326
Pol-Nef	26	11	7	26
Nef-Gag	3	1	1	3
*Total*	358	246	153	355
Unique epitope associations with epitopes from all three genes (Gag-Pol-Nef)	23	5	7	23

* Total number of associations includes all identified association rules that had a minimum support of 75% and 95% confidence. For CRFs, the support is 95%.
^# "Unique" rules combine associations between the same epitopes into a single, "unique" rule regardless of the order of epitopes within a rule (i.e., A occurs with B and B occurs with A are considered the same "unique" rule).
^$ i.e., association rules that involve two distinct CTL epitopes.

ISSN: 1742-4690